The manifesto of science of science has been published in Science magazine. This is a team effort involving 14 coauthors, three of whom are members of our center: Santo Fortunato (first and corresponding author), Staša Milojević and Filippo Radicchi. The team includes superstars in the field of complex systems like Albert-László Barabási, Dirk Helbing, Alessandro Vespignani, and Brian Uzzi. The paper is a review of the main research topics within science of science: knowledge networks, problem selection, novelty, career dynamics, team science and citation dynamics.