The use of mathematical modeling to better understand the origin and progression of life systems is the subject of American Scientist cover article Multiscale Modeling in Biology featuring the work of Prof. Santiago Schnell. A related paper authored by Schnell is ranked first among the Theoretical Biology & Medical Modelling most viewed articles of all time. This is a list of the most frequently accessed articles in the history of the journal, compiled using online access statistics of the publisher BioMedCentral. The article A multiscale mathematical model of cancer, and its use in analyzing irradiation therapies was coauthored with Benjamin Ribba and Thierry Colin, and appeared in Theoretical Biology and Medical Modelling 3:7 (2006). More...